![]() ![]() No laboratory can claim 100% accuracy because there are biological reasons why some samples don’t ‘behave’ properly during the analysis and may produce the wrong genotypes upon testing. At PPG, this is very rare, about 0.1% of the time, but it can happen. ![]() A false negative means that the laboratory mistakenly identified a carrier or at risk as clear/normal. Sometimes the same question is asked another way: What is your false positive rate? False positive means that the laboratory mistakenly identified a normal/clear as carrier or at risk. No laboratory can claim 100%, but at PPG, because we test your dog’s sample twice with two different methods, we have one of the highest accuracy rates in the industry. ![]() This all refers to whether the test result accurately reflects the true genotype of the individual. Specificity is defined as the proportion of samples with no known mutation that are correctly classified/identified with the wildtype (normal) genotype for the disease. Sensitivity is defined as the proportion of samples with a known mutation that are correctly classified/identified as carrier or at risk by their genotypes. At PPG, our tests are extensively validated and must show 99.9% specificity and sensitivity before being available for ordering. The first question being asked is: Does the test perform accurately to determine if a dog is normal/clear, a carrier of one copy of the mutation or at risk, having two copies of the mutation. It is important to understand the questions being asked so that the answers make sense. The customer is actually asking a couple of different questions one involving the accuracy of the test itself and one regarding the clinical validity of the test. As a laboratory that works directly with breeders and dog owners, Paw Print Genetics (PPG) is often asked to reassure the customer that our tests accurately determine whether a dog will get a disease. ![]()
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